How to get from Chicago to South Carolina
Find Transport to South Carolina
Search accommodation with Expedia
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.There are 11 ways to get from Chicago to South Carolina by plane, bus, train
or car
Bus via Atlanta
Bus
- Take the bus from Chicago to Atlanta
- Take the bus from Atlanta to Florence
Train via Rockville
- Take the train from Chicago Union Station to Rockville Amtrak
- Take the train from Washington Union Station to Florence Amtrak Station
Train
- Take the train from Chicago Union Station to Alexandria
- Take the train from Alexandria to Florence Amtrak Station
Drive
- Drive from Chicago to Florence
Travel safe during COVID-19
Rules to follow in United States
Travel within United States
Observe COVID-19 safety rules
Frequently Asked Questions
Am I allowed to travel from Chicago to South Carolina?
Yes, travel within United States is currently allowed.
Explore travel options
What are the travel restrictions in South Carolina?
Domestic travel is not restricted, but some conditions may apply
- Face masks are recommended
- There is a social distancing requirement of 2 metres
- Observe COVID-19 safety rules
Explore travel options
What is the national COVID-19 helpline number in South Carolina?
The national COVID-19 helpline number in South Carolina is 800-232-4636.
Do I have to wear a face mask on public transport in South Carolina?
Wearing a face mask on public transport in South Carolina is recommended.
What should I do if I have COVID-19 symptoms when I arrive in South Carolina?
Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.
Last updated: 16 Nov 2022
Exceptions may apply, for full details:
Centers for Disease control and prevention (CDC).
We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our
knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.
Questions & Answers
What is the cheapest way to get from Chicago to South Carolina?
The cheapest way to get from Chicago to South Carolina is to fly and bus which costs $140 - $550 and takes 5h 51m.
More details
What is the fastest way to get from Chicago to South Carolina?
The fastest way to get from Chicago to South Carolina is to fly which takes 3h 46m and costs $240 - $850.
More details
Is there a direct bus between Chicago and South Carolina?
No, there is no direct bus from Chicago to South Carolina. However, there are services departing from Chicago and arriving at Florence via Atlanta. The journey, including transfers, takes approximately 23h 10m.
More details
Is there a direct train between Chicago and South Carolina?
No, there is no direct train from Chicago station to South Carolina station. However, there are services departing from Chicago Union Station and arriving at Florence Amtrak Station via Rockville, Red Line Center Platform and Washington Union Station. The journey, including transfers, takes approximately 26h 8m.
More details
How far is it from Chicago to South Carolina?
The distance between Chicago and South Carolina is 1107 km. The road distance is 1411.6 km.
Get driving directions
How do I travel from Chicago to South Carolina without a car?
The best way to get from Chicago to South Carolina without a car is to bus via Atlanta which takes 21h 59m and costs $130 - $230.
More details
How long does it take to get from Chicago to South Carolina?
It takes approximately 3h 46m to get from Chicago to South Carolina, including transfers.
More details
Where do I catch the Chicago to South Carolina bus from?
Chicago to South Carolina bus services, operated by Greyhound USA, depart from Chicago station.
More details
Where do I catch the Chicago to South Carolina train from?
Chicago to South Carolina train services, operated by Amtrak, depart from Chicago Union Station.
More details
Train, bus or fly from Chicago to South Carolina?
The best way to get from Chicago to South Carolina is to fly which takes 3h 46m and costs $240 - $850. Alternatively, you can bus via Atlanta, which costs $130 - $230 and takes 21h 59m, you could also train via Rockville, which costs $180 - $260 and takes 26h 8m.
Mode details
What companies run services between Chicago, IL, USA and South Carolina, USA?
American Airlines, United Airlines and Delta fly from Chicago to Greenville hourly. Alternatively, you can take a bus from Chicago to Florence via Atlanta GA, Arts Center Station, Garnett Station, and Atlanta in around 21h 59m.
American Airlines
Websiteaa.comAve. Duration1h 47mWhenEvery dayEstimated price$230 - $800Ave. Duration4h 6mWhenEvery dayEstimated price$230 - $800 Ave. Duration4h 17mWhenMonday, Tuesday, Wednesday, Thursday, Friday and SundayEstimated price$240 - $850Ave. Duration2h 33mWhenEvery dayEstimated price$270 - $300Ave. Duration4h 7mWhenEvery dayEstimated price$270 - $300Ave. Duration4h 22mWhen Every dayEstimated price$324Ave. Duration4h 50mWhenEvery dayEstimated price$324Ave. Duration1h 58mWhenEvery dayEstimated price$460 - $950Ave. Duration3h 38mWhenMonday, Tuesday, Wednesday, Friday, Saturday and SundayEstimated price$460 - $950
United Airlines
Websiteunited.comAve. Duration1h 52m WhenEvery dayEstimated price$200 - $750Ave. Duration2h 12mWhenEvery dayEstimated price$240 - $340Ave. Duration2h 4mWhenEvery dayEstimated price$300 - $320Ave. Duration4h 51mWhenEvery dayEstimated price$300 - $320Ave. Duration1h 58mWhenEvery dayEstimated price$230 - $420
Southwest Airlines
Websitesouthwest.comAve. Duration2h 1mWhenEvery dayEstimated price$100 - $360Ave. Duration5hWhenSaturdayEstimated price$120 - $410Ave. Duration4h 8mWhenMonday, Tuesday, Wednesday, Saturday and SundayEstimated price$95 - $340Ave. Duration1h 46mWhenEvery dayEstimated price$120 - $440Ave. Duration4h 10mWhenMonday, Tuesday, Wednesday and SundayEstimated price$140 - $490Ave. Duration4h 20mWhenWednesdayEstimated price$150 - $550Ave. Duration4h 25mWhenMonday, Tuesday, Wednesday and SundayEstimated price$130 - $470
Delta
Websitedelta.comAve. Duration3h 49mWhenMonday, Tuesday, Wednesday, Friday, Saturday and SundayEstimated price$350 - $750Ave. Duration3h 57mWhenEvery dayEstimated price$360 - $750 Ave. Duration4h 3mWhenThursdayEstimated price$230 - $470Ave. Duration4h 15mWhenEvery dayEstimated price$470 - $1,000Ave. Duration4h 18mWhenEvery dayEstimated price$320 - $650
Amtrak
Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.
Phone+1 800-872-7245Websiteamtrak.comAve. Duration16h 36mFrequencyOnce dailyEstimated price$100 - $160WebsiteAmtrakCoach Seat$100 - $160Premium$390 - $550Flexi Coach Seat$210 - $320Business Seat$220 - $320Ave. Duration7h 46mFrequency3 times a day Estimated price$70 - $100WebsiteAmtrakCoach Seat$70 - $100Premium$320 - $440Flexi Coach Seat$130 - $200Business Seat$130 - $200 Ave. Duration23h 32mFrequency6 times a weekEstimated price$120 - $180WebsiteAmtrakCoach Seat$120 - $180Premium$420 - $600Flexi Coach Seat$250 - $370 Business Seat$270 - $380Ave. Duration7h 25mFrequency3 times a dayEstimated price$70 - $100WebsiteAmtrakCoach Seat$70 - $100Premium $310 - $440Flexi Coach Seat$130 - $190Business Seat$130 - $190Charlotte Area Transit System
Palmland Bus Lines
Southeastern Stages
Greyhound USA
Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.
Phone+1 214-849-8100/1-800-231-2222EmailWebsitegreyhound.comAve. Duration16h 5mFrequencyTwice dailyEstimated price$100 - $140Websitegreyhound.comEconomy$100 - $140Flexible$150 - $220Want to know more about travelling around United States
Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
More Questions & Answers
How long is the flight from Chicago to South Carolina?
The quickest flight from Chicago O'Hare Airport to Greenville/Spartanburg Airport is the direct flight which takes 1h 47m.
Search flights
Where does the Chicago to South Carolina bus arrive?
Chicago to South Carolina bus services, operated by Southeastern Stages, arrive at Florence station.
More details
What is the time difference between Chicago and South Carolina?
South Carolina is 1h ahead of Chicago. It is currently 23:54 in Chicago and 00:54 in South Carolina.
Where does the Chicago to South Carolina train arrive?
Chicago to South Carolina train services, operated by Amtrak, arrive at Florence Amtrak Station.
More details
Can I drive from Chicago to South Carolina?
Yes, the driving distance between Chicago to South Carolina is 1412 km. It takes approximately 14h 48m to drive from Chicago to South Carolina.
Get driving directions
Which airlines fly from Chicago O'Hare Airport to Greenville/Spartanburg Airport?
United Airlines, Delta and American Airlines offer flights from Chicago O'Hare Airport to Greenville/Spartanburg Airport.
Search flights
How do I get a train ticket from Chicago to South Carolina?
Book your Chicago to South Carolina train tickets online with Omio.
Search and book
Where can I stay near South Carolina?
There are 18+ hotels available in South Carolina. Prices start at $125 CAD per night.
More details
How do I get to Chicago O'Hare (ORD) Airport from Chicago?
The best way to get from Chicago to Chicago O'Hare Airport is to subway which takes 42 min and costs $1 - $7.
More details